Potassium Carbonate → HCID 68694827, compound

Participants

Reaction Steps

(3,5-Dihydroxy-phenyl)-acetic acid methyl ester (0.500 g, 2.75 mmol) in MeCN (5 ml) was treated with K2CO3 (0.095 g, 6.88 mmol) and 4-fluorobenzyl bromide (0.520 g, 2.75 mmol). The resultant mixture was stirred overnight at room temperature. The reaction mixture was directly purified by flash column chromatography (EtOAc:iso-hexane) to give [3-(4-fluoro-benzyloxy)-5-hydroxy-phenyl]-acetic acid methyl ester (0.15 g).

Provenance & Evidence