HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1169950Generated: October 28, 2026
Potassium Carbonate → [5-(4-Chloro-benzoxy)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid ethyl ester
https://huagongshe.com/reaction/1169950
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| Reactant | (5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester | HCID 66702499 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [5-(4-Chloro-benzoxy)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid ethyl ester | HCID 68694126 | 86.1% |
Reaction Steps
A suspension of (5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (70 mg, 0.22 mmol), K2CO3 (60 mg, 2.0 equivalents), 4-chlorobenzyl bromide (50 mg, 1.1 equivalents) in MeCN (2 mL) was heated at 80° C. for 2 hours. The resultant suspension was filtered and evaporated to dryness. The residue was purified by flash column chromatography (EtOAc:petroleum ether) to give 85 mg (83%) [5-(4-chloro-benzoxy)-4′-trifluoromethyl-biphenyl-3-yl]-acetic acid ethyl ester as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07825160B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-76c7332b320447f7a739ac4313bfd83d |
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| Source note | uspto-grants-2010_11 |
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