2-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole → 2-[(1R)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole

Participants

Reaction Steps

The compound of Example 1 (750 mg, 3.75 mmol) was dissolved in ethanol (4 ml) and the enantiomers were separated by automated preparative liquid chromatography (Gilson system, 50×50 mm ID Chiralcel OD, 20 μm column, 50 ml/min) using ethanol:hexane [10:90] as the mobile phase. The appropriate fractions were combined and concentrated to give the title compound (370 mg).

Provenance & Evidence