HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Amino-6-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Fluoro-6-(trifluoromethyl)benzonitrile | HCID 145613 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-6-(trifluoromethyl)benzonitrile | HCID 22625195 | — |
Reaction Steps
2-Fluoro-6-trifluoromethylbenzenecarbonitrile was heated at 100° C. in a saturated solution of NH3 in EtOH overnight. The reaction mixture was concentrated and the residue was purified by column chromatography on silicagel (EtOAc/Hexanes 1:5), to obtain the title compound as a white solid. GC/MS m/z 186.1 (M+), Rt 10.1 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825132B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-47660e2ec37140d6b48fbaac52452501 |
| Source note | uspto-grants-2010_11 |