Ethyl cyanoacetate → HCID 178510881, compound

HRID 1170000Notes

Reaction equation

HRID 1170000 reaction equation
[C:1]([CH2:3][C:4](OCC)=O)#[N:2].[NH2:9][C:10]1[C:15]([NH2:16])=[CH:14][CH:13]=[CH:12][N:11]=1>>[N:16]1[C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:4]=1[CH2:3][C:1]#[N:2]

Participants

3

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 99562,3-Diaminopyridine

Product 1

HCID 178510881HCID 178510881, compound

Procedure

Ethyl cyanoacetate (1.5 equivalents) and 2,3-diaminopyridine (1 equivalent) were heated at 185° C. for 30 minutes. The reaction mixture was cooled to room temperature and the black solid was triturated with ether. The desired product was thus obtained as a dark brown powder. LC/MS m/z 159.1 (MH+), Rt 0.44 minutes.

Workup

  1. customthe black solid was triturated with ether

Sources & evidence

ORD record
ord-1160950ecf8444dab7aa0ef1ca79fb9f
Source dataset
uspto-grants-2010_11
Patent number
US07825132B2

Reaction notes

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