Potassium Hydroxide → HCID 59857320, compound

HRID 1170027Notes

Reaction equation

HRID 1170027 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14]C(=O)C)=[C:10]([N+:18]([O-:20])=[O:19])[CH:9]=2)[CH2:4][CH2:3]1.[OH-].[K+]>CO>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[C:10]([N+:18]([O-:20])=[O:19])[CH:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68769508HCID 68769508, compound

Product 1

HCID 59857320HCID 59857320, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[4-(1-methyl(4-piperidyl))-2-nitrophenyl]acetamide (1 equivalent) was dissolved in methanol and 30% KOH (2.5 equivalents) was added dropwise with vigorous stirring. The reaction mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure. The residue was dissolved in CH2Cl2 and washed with water (2×) and brine (1×). The organic solution was dried (Na2SO4) and evaporated to obtain the desired product as an orange brown solid. MH+=236.2.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe residue was dissolved in CH2Cl2
  3. washwashed with water (2×) and brine (1×)
  4. dry with materialThe organic solution was dried (Na2SO4)
  5. customevaporated

Sources & evidence

ORD record
ord-db6a4a911f354220b6d89dae6732cfdd
Source dataset
uspto-grants-2010_11
Patent number
US07825132B2

Reaction notes

Loading…