Potassium Hydroxide → HCID 178515968, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.9 g (8.0 mmol) of tris(3-(6-methoxy-2-pyridyl)benzyl)methane and 7.4 g (64 mmol) of pyridinium hydrochloride was heated at 190° C. for 3 h. After cooling, the mixture was taken up in 200 ml of water and adjusted to pH=7.7 using 1N potassium hydroxide solution. The aqueous phase was extracted five times with 200 ml of dichloromethane. The organic phase was dried over magnesium sulfate and filtered through a short frit with silica gel. After removal of the solvent, the residue was recrystallised from tert-butyl methyl ether:n-heptane (1:2). The yield, with a purity of about 97%, was 3.8 g (6.7 mmol), corresponding to 83.8% of theory.

Provenance & Evidence