3,5-Difluoroaniline → N5-(3,5-Difluoro-phenyl)-N2-(5-methyl-furan-2-ylmethyl)-quinoline-2,5-diamine

HRID 1170114Notes

Reaction equation

HRID 1170114 reaction equation
I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[CH3:13][C:14]1[O:18][C:17]([CH2:19][NH2:20])=[CH:16][CH:15]=1.[F:21][C:22]1[CH:23]=[C:24]([CH:26]=[C:27]([F:29])[CH:28]=1)[NH2:25]>>[F:21][C:22]1[CH:23]=[C:24]([NH:25][C:2]2[C:3]3[CH:4]=[CH:5][C:6]([NH:20][CH2:19][C:17]4[O:18][C:14]([CH3:13])=[CH:15][CH:16]=4)=[N:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH:26]=[C:27]([F:29])[CH:28]=1

Participants

4

Reactant 3

HCID 965953,5-DifluoroanilineHCID 27246835-Methyl-2-furylmethylamineHCID 457894242-Chloro-5-iodoquinoline

Product 1

HCID 68434032N5-(3,5-Difluoro-phenyl)-N2-(5-methyl-furan-2-ylmethyl)-quinoline-2,5-diamine

Procedure

The title compound, MS: m/e=366.1 (M+H+), was prepared in accordance with the general method of example 1 from 5-iodo-2-chloroquinoline (CAS 455955-26-7), 5-methyl-2-furanmethanamine and 3,5-difluoroaniline.

Sources & evidence

ORD record
ord-f5611239c5eb40448b2b12dc7ce67eec
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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