2-Methoxybenzylamine → (2-Methoxy-benzyl)-[5-(3-methoxy-benzyloxy)-quinolin-2-yl]-amine

HRID 1170125Notes

Reaction equation

HRID 1170125 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH2:18].[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28]Br>>[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH:18][C:6]1[CH:5]=[CH:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[O:1][CH2:28][C:27]2[CH:30]=[CH:31][CH:32]=[C:25]([O:24][CH3:23])[CH:26]=2)[N:7]=1

Participants

4

Reactant 3

HCID 812922-MethoxybenzylamineHCID 40672073-Methoxybenzyl bromideHCID 1354422212-chloroquinolin-5-ol

Product 1

HCID 68436700(2-Methoxy-benzyl)-[5-(3-methoxy-benzyloxy)-quinolin-2-yl]-amine

Procedure

The title compound, MS: m/e=401.3 (M+H+), was prepared in accordance with the general method of example 63 from 5-hydroxy-2-chloroquinoline (CAS 124467-35-2), 2-methoxy benzyl amine and 3-methoxy benzyl bromide.

Sources & evidence

ORD record
ord-e1fcee203265424a86f7cd4dc31f46ef
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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