5-Methyl-2-furylmethylamine → (5-Methyl-furan-2-ylmethyl)-[5-(pyridin-3-ylmethoxy)-quinolin-2-yl]-amine

HRID 1170126Notes

Reaction equation

HRID 1170126 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH:19](Br)C2C=CC=CC=2)[CH:14]=1.[CH3:27][C:28]1[O:32][C:31]([CH2:33][NH2:34])=[CH:30][CH:29]=1>>[CH3:27][C:28]1[O:32][C:31]([CH2:33][NH:34][C:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[O:1][CH2:19][C:15]3[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=3)[N:7]=2)=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 27246835-Methyl-2-furylmethylamineHCID 684362043-Pyridyl benzyl bromideHCID 1354422212-chloroquinolin-5-ol

Product 1

HCID 68435844(5-Methyl-furan-2-ylmethyl)-[5-(pyridin-3-ylmethoxy)-quinolin-2-yl]-amine

Procedure

The title compound, MS: m/e=346.3 (M+H+), was prepared in accordance with the general method of example 63 from 5-hydroxy-2-chloroquinoline (CAS 124467-35-2), 3-pyridyl benzyl bromide and 5-methyl-2-furanmethanamine.

Sources & evidence

ORD record
ord-c0de85961d0a4ff690737b8cdf0357c0
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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