4-(Methylsulfonyl)aniline → N5-(4-Methanesulfonyl-phenyl)-N2-(5-methyl-furan-2-ylmethyl)-quinoline-2,5-diamine
Reaction equation
I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[CH3:13][C:14]1[O:18][C:17]([CH2:19][NH2:20])=[CH:16][CH:15]=1.[CH3:21][S:22]([C:25]1[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=1)(=[O:24])=[O:23]>>[CH3:21][S:22]([C:25]1[CH:31]=[CH:30][C:28]([NH:29][C:2]2[C:3]3[CH:4]=[CH:5][C:6]([NH:20][CH2:19][C:17]4[O:18][C:14]([CH3:13])=[CH:15][CH:16]=4)=[N:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)=[CH:27][CH:26]=1)(=[O:23])=[O:24]Participants
4
Procedure
The title compound, MS: m/e=408.3 (M+H+), was prepared in accordance with the general method of example 1 from 5-iodo-2-chloroquinoline (CAS 455955-26-7), 5-methyl-2-furanmethanamine and 4-methylsulfonylaniline.
Sources & evidence
- ORD record
- ord-61ffe90592184e5b878830ff2d05725b
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07825253B2
Reaction notes
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