HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitroquinoline → 3,4,5-Trifluoro-N-{2-[(R)-1-(2-methoxy-phenyl)-ethylamino]-quinolin-5-yl}-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitroquinoline | HCID 319251 | — |
| Reactant | (R)-1-(2-Methoxyphenyl)ethanamine | HCID 853083 | — |
| Reactant | 3,4,5-Trifluorobenzenesulfonyl chloride | HCID 2778858 | — |
| Product | 3,4,5-Trifluoro-N-{2-[(R)-1-(2-methoxy-phenyl)-ethylamino]-quinolin-5-yl}-benzenesulfonamide | HCID 68436827 | — |
Reaction Steps
The title compound, MS: m/e=488.3 (M+H+), was prepared in accordance with the general method of example 61 from 5-nitro-2-chloroquinoline, 3,4,5-trifluorobenzenesulfonylchloride and (R)-2-methoxy-alpha-methylbenzylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825253B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-0f952d4de500425c9771ffff848e145e |
| Source note | uspto-grants-2010_11 |