2-Chloro-5-nitroquinoline → HCID 24988600, compound

HRID 1170141Notes

Reaction equation

HRID 1170141 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[CH3:27][C:28]1[O:32][C:31]([CH:33]([NH2:35])[CH3:34])=[CH:30][CH:29]=1>>[F:15][C:16]1[CH:17]=[C:18]([S:23]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:35][CH:33]([C:31]2[O:32][C:28]([CH3:27])=[CH:29][CH:30]=2)[CH3:34])=[N:9]3)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 39648081-(5-Methyl-furan-2-yl)-ethylamine

Product 1

HCID 24988600HCID 24988600, compound

Procedure

The title compound, MS: m/e=444.4 (M+H+), was prepared in accordance with the general method of example 61 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonylchloride and 1-(5-methyl-2-furyl) ethanamine.

Sources & evidence

ORD record
ord-00b2a11bd5f644be9b032026260b87d2
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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