2-Chloro-5-nitroquinoline → N-(2-chloro-quinolin-5-yl)-3,5-difluoro-benzenesulfonamide

HRID 1170143Notes

Reaction equation

HRID 1170143 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8]([Cl:14])=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1>>[Cl:14][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[CH:13][C:4]=2[NH:1][S:23]([C:18]2[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=2)(=[O:25])=[O:24])[N:9]=1

Participants

3

Reactant 2

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chloride

Product 1

HCID 86619497N-(2-chloro-quinolin-5-yl)-3,5-difluoro-benzenesulfonamide

Procedure

The intermediate N-(2-chloro-quinolin-5-yl)-3,5-difluoro-benzenesulfonamide was prepared in accordance with the general method of example 61, step A and B from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonylchloride.

Sources & evidence

ORD record
ord-86c8603794aa4c99be07a07fa567aafa
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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