2-Chloro-5-nitroquinoline → HCID 24989722, compound

HRID 1170157Notes

Reaction equation

HRID 1170157 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[CH3:15][C:16]1[O:20][C:19]([CH2:21][NH2:22])=[CH:18][CH:17]=1.[CH3:23][N:24]1[C:29]2[CH:30]=[CH:31][C:32]([CH:34]=O)=[CH:33][C:28]=2[O:27][CH2:26][CH2:25]1>>[CH3:23][N:24]1[C:29]2[CH:30]=[CH:31][C:32]([CH2:34][NH:1][C:4]3[C:5]4[CH:6]=[CH:7][C:8]([NH:22][CH2:21][C:19]5[O:20][C:16]([CH3:15])=[CH:17][CH:18]=5)=[N:9][C:10]=4[CH:11]=[CH:12][CH:13]=3)=[CH:33][C:28]=2[O:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27246835-Methyl-2-furylmethylamineHCID 27764044-Methyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbaldehyde

Product 1

HCID 24989722HCID 24989722, compound

Procedure

The title compound, MS: m/e=388.4 (M+H+), was prepared from 5-nitro-2-chloroquinoline, 5-methyl-2-furanmethanamine and 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbaldehyde as described in example 26.

Sources & evidence

ORD record
ord-85bc93b3dc754ca68529830adf94c885
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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