2-Chloro-5-nitroquinoline → HCID 24990825, compound

HRID 1170173Notes

Reaction equation

HRID 1170173 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[NH2:27][C:28]1[C:37]2[O:36][CH2:35][CH2:34][O:33][C:32]=2[CH:31]=[CH:30][CH:29]=1>>[O:33]1[C:32]2[CH:31]=[CH:30][CH:29]=[C:28]([NH:27][C:8]3[CH:7]=[CH:6][C:5]4[C:10](=[CH:11][CH:12]=[CH:13][C:4]=4[NH:1][S:23]([C:18]4[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=4)(=[O:25])=[O:24])[N:9]=3)[C:37]=2[O:36][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 117883872,3-Dihydro-1,4-benzodioxin-5-amine

Product 1

HCID 24990825HCID 24990825, compound

Procedure

The title compound, MS: m/e=470.3 (M+H+), was prepared in accordance with the general method of example 89 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonylchloride and 5-amino-1,4-benzodioxane.

Sources & evidence

ORD record
ord-af8d0a7f155540f7986a225a04c3e402
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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