HCID 67333492, compound → HCID 68437142, compound

Participants

Reaction Steps

Hydrogenation of 2-[(5-methyl-furan-2-ylmethyl)-amino]-quinoline-5-carbonitrile (200 mg, 0.76 mmol) dissolved in 7N MeOH—NH3 for 23 h at room temperature yielded after removal of the catalyst by filtration and evaporation a yellow oil which was further purified by column chromatography (dichloromethane/MeOH/NH4OH 15:1:0.1) on silica gel to yield (5-aminomethyl-quinolin-2-yl)-(5-methyl-furan-2-ylmethyl)-amine as light yellow oil (198 mg, 98%).

Provenance & Evidence