2-Chloro-5-nitroquinoline → HCID 24991556, compound

HRID 1170184Notes

Reaction equation

HRID 1170184 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[CH3:15][C:16]1[O:17][C:18]2[C:24]([NH2:25])=[CH:23][CH:22]=[CH:21][C:19]=2[CH:20]=1.[F:26][C:27]1[CH:28]=[C:29]([CH:32]=[C:33]([F:35])[CH:34]=1)[CH:30]=O>>[F:26][C:27]1[CH:28]=[C:29]([CH:32]=[C:33]([F:35])[CH:34]=1)[CH2:30][NH:1][C:4]1[C:5]2[CH:6]=[CH:7][C:8]([NH:25][C:24]3[C:18]4[O:17][C:16]([CH3:15])=[CH:20][C:19]=4[CH:21]=[CH:22][CH:23]=3)=[N:9][C:10]=2[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 5881603,5-DifluorobenzaldehydeHCID 31574852-Methyl-benzofuran-7-ylamine

Product 1

HCID 24991556HCID 24991556, compound

Procedure

The title compound, MS: m/e=416.4 (M+H+), was prepared from 5-nitro-2-chloroquinoline, (2-methyl-1-benzofuran-7-yl)amine and 3,5-difluorobenzaldehyde as described in example 26.

Sources & evidence

ORD record
ord-ff09ae32326343c7a8f0ef40c819cb5a
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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