2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine → HCID 24991901, compound

HRID 1170194Notes

Reaction equation

HRID 1170194 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[NH2:27][C:28]1[C:36]2[O:35][C:34]([CH3:38])([CH3:37])[CH2:33][C:32]=2[CH:31]=[CH:30][CH:29]=1>>[CH3:37][C:34]1([CH3:38])[CH2:33][C:32]2[CH:31]=[CH:30][CH:29]=[C:28]([NH:27][C:8]3[CH:7]=[CH:6][C:5]4[C:10](=[CH:11][CH:12]=[CH:13][C:4]=4[NH:1][S:23]([C:18]4[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=4)(=[O:25])=[O:24])[N:9]=3)[C:36]=2[O:35]1

Participants

4

Reactant 3

HCID 916972,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amineHCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chloride

Product 1

HCID 24991901HCID 24991901, compound

Procedure

The title compound, MS: m/e=482.1 (M+H+), was prepared in accordance with the general method of example 89 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonylchloride and 7-amino-2,3-dihydro-2,2-dimethylbenzofuran (CAS 68298-46-4).

Sources & evidence

ORD record
ord-8b4a1fddefed45319a87dbbecebddd9b
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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