2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine → HCID 178433272, compound

HRID 1170199Notes

Reaction equation

HRID 1170199 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[NH2:15][C:16]1[C:24]2[O:23][C:22]([CH3:26])([CH3:25])[CH2:21][C:20]=2[CH:19]=[CH:18][CH:17]=1.[CH3:27][C:28]1[N:29]=[CH:30][NH:31][C:32]=1[CH:33]=O>>[CH3:25][C:22]1([CH3:26])[CH2:21][C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:15][C:8]3[CH:7]=[CH:6][C:5]4[C:4]([NH:1][CH2:27][C:28]5[NH:29][CH:30]=[N:31][C:32]=5[CH3:33])=[CH:13][CH:12]=[CH:11][C:10]=4[N:9]=3)[C:24]=2[O:23]1

Participants

4

Reactant 3

HCID 916972,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amineHCID 3192512-Chloro-5-nitroquinolineHCID 27958875-Methyl-1H-imidazole-4-carbaldehyde

Product 1

HCID 178433272HCID 178433272, compound

Procedure

The title compound, MS: m/e=400.4 (M+H+), was prepared from 5-nitro-2-chloroquinoline, 7-amino-2,3-dihydro-2,2-dimethylbenzofuran (CAS 68298-46-4) and 4-methyl-1H-imidazole-5-carbaldehyde as described in example 26.

Sources & evidence

ORD record
ord-282ea1d09b1e4da79518cd83d9ebdaf5
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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