2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine → Rac-n5-[1-(3,5-difluoro-phenyl)-ethyl]-n2-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-quinoline-2,5-diamine

HRID 1170202Notes

Reaction equation

HRID 1170202 reaction equation
I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[NH2:13][C:14]1[C:22]2[O:21][C:20]([CH3:24])([CH3:23])[CH2:19][C:18]=2[CH:17]=[CH:16][CH:15]=1.[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH2:35])[CH3:34])[CH:29]=[C:30]([F:32])[CH:31]=1>>[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH:35][C:2]2[C:3]3[CH:4]=[CH:5][C:6]([NH:13][C:14]4[C:22]5[O:21][C:20]([CH3:24])([CH3:23])[CH2:19][C:18]=5[CH:17]=[CH:16][CH:15]=4)=[N:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH3:34])[CH:29]=[C:30]([F:32])[CH:31]=1

Participants

4

Reactant 3

HCID 916972,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amineHCID 2783196(RS)-1-(3,5-Difluorophenyl)ethylamineHCID 457894242-Chloro-5-iodoquinoline

Product 1

HCID 24986420Rac-n5-[1-(3,5-difluoro-phenyl)-ethyl]-n2-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-quinoline-2,5-diamine

Procedure

The title compound, MS: m/e=446.1 (M+H+), was prepared in accordance with the general method of example 1 from 5-iodo-2-chloroquinoline, 7-amino-2,3-dihydro-2,2-dimethylbenzofuran (CAS 68298-46-4) and rac-1-(3,5-difluorophenyl)ethylamine.

Sources & evidence

ORD record
ord-454036527ab949f6ae9e2ec42b261610
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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