2-Chloro-5-nitroquinoline → N-[2-(3-Cyclopropyl-phenylamino)-quinolin-5-yl]-3,5-difluoro-benzenesulfonamide

HRID 1170207Notes

Reaction equation

HRID 1170207 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[CH:27]1([C:30]2[CH:31]=[C:32]([CH:34]=[CH:35][CH:36]=2)[NH2:33])[CH2:29][CH2:28]1>>[CH:27]1([C:30]2[CH:31]=[C:32]([NH:33][C:8]3[CH:7]=[CH:6][C:5]4[C:10](=[CH:11][CH:12]=[CH:13][C:4]=4[NH:1][S:23]([C:18]4[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=4)(=[O:25])=[O:24])[N:9]=3)[CH:34]=[CH:35][CH:36]=2)[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 120321393-Cyclopropylaniline

Product 1

HCID 24986781N-[2-(3-Cyclopropyl-phenylamino)-quinolin-5-yl]-3,5-difluoro-benzenesulfonamide

Procedure

The title compound, MS: m/e=452.0 (M+H+), was prepared in accordance with the general method of example 89 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonylchloride and 3-cyclopropylaniline.

Sources & evidence

ORD record
ord-133e014b8c7c4797bd4630fa0e742a59
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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