反应详情

4-(7-Piperazin-1-yl-quinazolin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.1 mmol), prepared as described in Example 45, was added to a mixture of t-butoxyacetic acid (0.15 mmol) and PS-carbodiimide (0.2 mmol) in anhydrous DCM (2 mL). The mixture was shaken at rt overnight. It was then filtered and the resin washed with DCM. The combined filtrate and washings were concentrated in vacuo. To this was then added 3M HCl/MeOH (2 mL) and stirred at rt for 2 h and then concentrated in vacuo.

1. filtrationIt was then filtered
2. washthe resin washed with DCM
3. concentrationThe combined filtrate and washings were concentrated in vacuo
4. additionTo this was then added 3M HCl/MeOH (2 mL)
5. stirringstirred at rt for 2 h
6. concentrationconcentrated in vacuo