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HRID 1170282作成日：2026年10月26日

7-Chloro-2-(chloromethyl)quinoline → 7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride

https://huagongshe.com/reaction/1170282

反応式

関与物質

役割名称HCID仕込み量
反応物7-Chloro-2-(chloromethyl)quinolineHCID 10954844—
反応物Methyl 4-(2-quinolinylmethoxy)benzoateHCID 19934817—
反応物4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]PhenolHCID 135915213—
生成物7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chlorideHCID 11561731—

反応手順

Following the procedure for the preparation of 4-(Quinolin-2-ylmethoxy)-benzoic acid methyl ester but substituting 4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenol and 7-chloro-2-chloromethyl-quinoline provided the title compound. 1H NMR (400 MHz, DMSO) δ 8.66 (d, J=6.6 Hz, 2H), 8.54 (s, 1H), 8.47 (d, J=8.3, 2H), 8.04 (m, 2H), 7.70 (m, 2H), 7.65 (m, 1H), 7.36 (d, J=8.7 Hz, 2H), 7.12 (d, J=8.7, 2H), 5.38 (s, 2H), 3.90 (s, 3H); MS: (M+H m/z=427.1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07825254B2
出典データセットuspto-grants-2010_11
ORD IDord-90cd2d858fa64a608eb9c7e64d80f175
出典メモuspto-grants-2010_11