3-Chloro4-(quinolin-2-ylmethoxy)-benzoic acid → 3-Chloro-N-methoxy-N-methyl4-(quinolin-2-ylmethoxy)-benzamide

HRID 1170318Notes

Reaction equation

HRID 1170318 reaction equation
[CH3:1][O:2][N:3](C)[C:4](=O)C1C=CC(CCC2C=CC3C(=CC=CC=3)N=2)=CC=1.[Cl:25][C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][C:34]=1[O:35][CH2:36][C:37]1[CH:46]=[CH:45][C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:38]=1)[C:29]([OH:31])=O>>[Cl:25][C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][C:34]=1[O:35][CH2:36][C:37]1[CH:46]=[CH:45][C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:38]=1)[C:29]([N:3]([O:2][CH3:1])[CH3:4])=[O:31]

Participants

3

Reactant 2

HCID 685787133-Chloro4-(quinolin-2-ylmethoxy)-benzoic acidHCID 86249320N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide

Product 1

HCID 862493473-Chloro-N-methoxy-N-methyl4-(quinolin-2-ylmethoxy)-benzamide

Procedure

Following the procedure for the preparation of N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide but substituting 3-Chloro-4-(quinolin-2-ylmethoxy)-benzoic acid provided the title compound. (M+H m/z=356.9).

Sources & evidence

ORD record
ord-268c13f792734dd382c2706418c4d7db
Source dataset
uspto-grants-2010_11
Patent number
US07825254B2

Reaction notes

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