참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-(Chloromethyl)quinoline | HCID 20394 | — |
| 반응물 | 4-Hydroxybenzamide | HCID 65052 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(Quinolin-2-ylmethoxy)benzamide | HCID 44088007 | 45% |
반응 단계
To a solution of 2-Chloromethyl-quinoline (1.57 g) and 4-Hydroxy-benzamide (995 mg) in dimethyl formamide (20 mL) was added cesium carbonate (7.3 g) and the reaction mixture heated at 80° C. for 18 h. The reaction mixture was poured into water and extracted with chloroform, dried magnesium sulfate, filtered and concentrated to provided the title compound (909 mg). MS: (M+H m/z=279.3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07825254B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_11 |
|---|
| ORD ID | ord-5743264ace834e36b1e38286235b5310 |
|---|
| 출처 메모 | uspto-grants-2010_11 |
|---|
