反应详情

温度

5 °C

5.0 g (32 mmol) of 8-quinolinecarbaldehyde were added to a solution of 5.6 g (48 mmol) of tert-butyl carbamate and 8.5 g (48 mmol) of sodium p-toluenesulfonate in 112 ml of acetonitrile under argon. While cooling to 0-10° C., 6.9 g (64 mmol) of chlorotrimethylsilane were added dropwise, and the mixture was left to stir at room temperature overnight. After addition of 130 ml of water, the precipitated product was filtered off with suction and dried in vacuo at 50° C. 11.4 g of tert-butyl [quinolin-8-yl(toluene-4-sulfonyl)methyl]carbamate were obtained.

1. waitthe mixture was left
2. filtrationthe precipitated product was filtered off with suction
3. customdried in vacuo at 50° C