Sodium Hydroxide → HCID 178464153, compound

HRID 1170423Notes

Reaction equation

HRID 1170423 reaction equation
Cl.[CH2:2]([N:4]([CH2:10][CH3:11])[C@H:5]1[CH2:8][C@H:7]([OH:9])[CH2:6]1)[CH3:3].[OH-].[Na+]>CO>[CH2:2]([N:4]([CH2:10][CH3:11])[C@H:5]1[CH2:8][C@H:7]([OH:9])[CH2:6]1)[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178464155HCID 178464155, compound

Product 1

HCID 178464153HCID 178464153, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Trans-1-diethylamino-3-hydroxycyclobutane hydrochloride (197 mg, 1.10 mmol) was dissolved in methanol (3.0 mL), and thereto was added 1N aqueous sodium hydroxide solution (1.10 mL, 1.10 mmol). The mixture was evaporated, and thereto were added ethyl acetate and tetrahydrofuran, and the mixture was dried over sodium sulfate, and filtered. The filtrate was evaporated to give the titled compound.

Workup

  1. customThe mixture was evaporated
  2. additionwere added ethyl acetate and tetrahydrofuran
  3. dry with materialthe mixture was dried over sodium sulfate
  4. filtrationfiltered
  5. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-496f630436b24dd0acbef9c9c8bfe2e4
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

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