HCID 178464130, compound → HCID 178464131, compound

HRID 1170430Notes

Reaction equation

HRID 1170430 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[Mg]Br.[CH2:10]([N:12]([CH2:34][CH3:35])[C@H:13]1[CH2:16][C@H:15]([CH2:17][N:18]2[C:26]3[C:21](=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:23]=[C:24]([I:27])[CH:25]=3)[C:20](=[O:32])[C:19]2=[O:33])[CH2:14]1)[CH3:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:20]1([OH:32])[C:21]2[C:26](=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[C:28]([F:30])([F:31])[F:29])[N:18]([CH2:17][C@H:15]2[CH2:14][C@H:13]([N:12]([CH2:10][CH3:11])[CH2:34][CH3:35])[CH2:16]2)[C:19]1=[O:33]

Participants

3

Reactant 2

HCID 178464130HCID 178464130, compoundHCID 178478041HCID 178478041, compound

Product 1

HCID 178464131HCID 178464131, compoundYield 74%

Procedure

2-chlorophenylmagnesium bromide (0.35 mmol) and the compound of Example 1-1 were reacted in a similar manner to Example 1-2 to give the titled compound (50.4 mg, 74%).

Sources & evidence

ORD record
ord-0cb93c6e0f2345a98cb4457be2853e13
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

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