Diethylamine → HCID 178464220, compound

Participants

Reaction Steps

To a solution of aluminum trichloride (533 mg, 4 mmol) in dichloromethane (4 mL) were added diethylamine (1.67 mL, 16 mmol) and benzyl cis-3-hydroxycyclobutane carboxylate (413 mg, 2.0 mmol) at 0° C., and then the mixture was stirred at room temperature for 24 hours. To the reaction solution was added saturated aqueous sodium bicarbonate, and the mixture was filtered through celite, and then extracted with ethyl acetate, dried over magnesium sulfate and filtered. The filtrate was evaporated and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1 to 0/1, ethyl acetate/methanol=9/1) to give the titled compound (321 mg, 94%).

Provenance & Evidence