Water → HCID 178464022, compound

Participants

Reaction Steps

To a solution of lithium aluminum hydride (78.4 mg, 2.07 mmol) in tetrahydrofuran (3.8 mL) was added the compound of Example 3-1 (322 mg, 1.88 mmol), and the mixture was heated to reflux for 3 hours. To the reaction solution were successively added water (79 μL), 4M aqueous sodium hydroxide solution (79 μL) and water (237 μL) at room temperature, and the mixture was filtered through celite. The filtrate was concentrated to give the titled compound (282 mg, 96%).

Provenance & Evidence