Tetrabutylammonium Fluoride → HCID 178464132, compound

Participants

Reaction Steps

To a solution of the compound of Example 14-2 (160 mg, 0.234 mmol) in tetrahydrofuran (6 mL) was added tetra-n-butylammonium fluoride (100 mg, 0.383 mmol) under nitrogen, and the mixture was stirred at room temperature for 2 hours. To the reaction solution was added, and the mixture was extracted with ethyl acetate, and then the organic layer was washed with saturated saline, dried over magnesium sulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel chromatography (chloroform/methanol=10/1) to give the titled compound (80 mg, 60%).

Provenance & Evidence