Hydrate;hydrochloride → HCID 178464140, compound

HRID 1170445Notes

Reaction equation

HRID 1170445 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([N:22]3[CH:26]=[CH:25][N:24]=[N:23]3)=[CH:15][C:16]=2[C:18]([F:21])([F:20])[F:19])[N:11]([CH2:27][C@H:28]2[CH2:31][C@H:30]([N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])[CH2:29]2)[C:10]1=[O:37].O.Cl>C(#N)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([N:22]3[CH:26]=[CH:25][N:24]=[N:23]3)=[CH:15][C:16]=2[C:18]([F:20])([F:19])[F:21])[N:11]([CH2:27][C@H:28]2[CH2:29][C@H:30]([N:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[CH2:31]2)[C:10]1=[O:37]

Participants

4

Reactant 2

HCID 21885828Hydrate;hydrochlorideHCID 178464139HCID 178464139, compound

Product 1

HCID 178464140HCID 178464140, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of the compound of Example 16-1 in acetonitrile was added 4N hydrochloric acid water, and the mixture was concentrated in vacuo and dried to give the titled compound.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customdried

Sources & evidence

ORD record
ord-4dee80ac3b9240b4ac3312a8da220c77
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

Loading…