Hydrate;hydrochloride → HCID 178464142, compound

HRID 1170447Notes

Reaction equation

HRID 1170447 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([N:22]3[N:26]=[N:25][CH:24]=[N:23]3)=[CH:15][C:16]=2[C:18]([F:21])([F:20])[F:19])[N:11]([CH2:27][C@H:28]2[CH2:31][C@H:30]([N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])[CH2:29]2)[C:10]1=[O:37].O.Cl>C(#N)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([N:22]3[N:26]=[N:25][CH:24]=[N:23]3)=[CH:15][C:16]=2[C:18]([F:21])([F:19])[F:20])[N:11]([CH2:27][C@H:28]2[CH2:29][C@H:30]([N:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[CH2:31]2)[C:10]1=[O:37]

Participants

4

Reactant 2

HCID 21885828Hydrate;hydrochlorideHCID 178464141HCID 178464141, compound

Product 1

HCID 178464142HCID 178464142, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of the compound of Example 17-1 in acetonitrile was added 4N hydrochloric acid water, and then the mixture was concentrated in vacuo and dried to give the titled compound.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customdried

Sources & evidence

ORD record
ord-708dfaad456e4841a9cfcd07aed32dbb
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

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