HRID1170447

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21885828

hydrate;hydrochloride

H3ClO

结构：CCN(CC)[C@H]1C[C@H](CN2C(=O)C(O)(c3ccc(Cl)cc3Cl)c3c2cc(-n2ncnn2)cc3C(F)(F)F)C1

HCID178464141

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)[C@H]1C[C@H](CN2C(=O)C(O)(c3ccc(Cl)cc3Cl)c3c2cc(-n2ncnn2)cc3C(F)(F)F)C1.Cl

HCID178464142

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

To a solution of the compound of Example 17-1 in acetonitrile was added 4N hydrochloric acid water, and then the mixture was concentrated in vacuo and dried to give the titled compound.

WORKUP

后处理

concentrationthe mixture was concentrated in vacuo
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-708dfaad456e4841a9cfcd07aed32dbb
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07825155B2
来源说明: uspto-grants-2010_11

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([N:22]3[N:26]=[N:25][CH:24]=[N:23]3)=[CH:15][C:16]=2[C:18]([F:21])([F:20])[F:19])[N:11]([CH2:27][C@H:28]2[CH2:31][C@H:30]([N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])[CH2:29]2)[C:10]1=[O:37].O.Cl>C(#N)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([N:22]3[N:26]=[N:25][CH:24]=[N:23]3)=[CH:15][C:16]=2[C:18]([F:21])([F:19])[F:20])[N:11]([CH2:27][C@H:28]2[CH2:29][C@H:30]([N:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[CH2:31]2)[C:10]1=[O:37]