Hydrochloric Acid → HCID 178478783, compound

Participants

Reaction Steps

The N′,N″-di-BOC-guanidine (4a) (0.25 g, 0.4 mmol) was dissolved in CH2Cl2 (10 mL), diluted with dry EtOH (15 mL) and the chilled solution was saturated with dry HCl. The reaction was then kept stirring at room temperature for 3 days (drying tube), when by the product started forming a precipitate over time. After evaporating the solvent to dryness, the residue was washed with ether multiple times and was dried under vacuum at 50-60° C. over night to give whitish yellow solid of the bis-guanidine dihydrochloride (0.13 g, quantitative), mp>340° C. 1H-NMR (DMSO-d6): δ 3.95 (s, 2H), 7.24 (d, J=8.4 Hz, 2H), 7.45 (s, 2H), 7.58 (br s, 8H), 7.95 (d, J=8.4 Hz, 2H), 10.23 (br s, 2H). 13C-NMR (DMSO-d6): δ 156.1, 156.1, 144.5, 138.6, 133.8, 123.3, 121.4, 120.9, 36.8. MS (EI): m/z 277 (M++1) (14), 252 (100). Anal. Calcd. for C15H16N6.2HCl-0.25C2H5OH (364.76): C % 51.04, H % 5.39, N % 23.04, Cl % 19.44. Found: C % 50.74, H % 5.26, N % 22.99, Cl % 19.87.

Provenance & Evidence