Potassium Carbonate → HCID 58654500, compound

Participants

Reaction Steps

A solution of (benzhydrylidene-amino)-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-acetic acid ethyl ester (460 mg, 1.10 mmol) in THF (4 mL), water (3 mL) and hydrochloride acid (1 mL, 37%) was stirred at r.t for 0.5 h. The saturated K2CO3 solution was added to make the solution basic (pH 9). The mixture was extracted with ethyl acetate (2×100 mL), washed with brine and dried over Na2SO4. Evaporation of the solvent and purification by column chromatography gave 200 mg (70%) of amino-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-acetic acid ethyl ester. [M+H]+ 262.64.

Provenance & Evidence