HCID 24275350, compound → HCID 11603670, compound

HRID 1170491Notes

Reaction equation

HRID 1170491 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][CH3:18])[CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1.Cl[C:20]1[S:24][N:23]=[C:22]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[N:21]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[CH2:15][CH2:14][CH:13]([CH2:16][N:17]([C:20]4[S:24][N:23]=[C:22]([N:25]5[CH:29]=[CH:28][N:27]=[CH:26]5)[N:21]=4)[CH3:18])[CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 24275350HCID 24275350, compoundHCID 452743615-Chloro-3-(1H-imidazol-1-yl)-1,2,4-thiadiazole

Product 1

HCID 11603670HCID 11603670, compound

Procedure

(1-Benzo[1,3]dioxol-5-ylmethyl-pyrrolidin-3-ylmethyl)-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-methyl-amine was prepared following the procedures described in the preparation of Example 23 in Step 3 using (1-benzo[1,3]dioxol-5-ylmethyl-pyrrolidin-3-ylmethyl)-methyl-amine and 5-chloro-3-imidazol-1-yl-[1,2,4]thiadiazole. [M+H]+ 398.99; 1H NMR (400 MHz, CDCl3) δ 8.28 (s, 1H), 7.63 (s, 1H), 7.06 (s, 1H), 6.81 (s, 1H), 6.70-6.67 (m, 2H), 5.89 (s, 2H), 3.14 (s, 2H), 2.92 (s, 2H), 2.90 (m, 2H), 2.65-2.47 (m, 2H), 2.58 (s, 3H), 2.00 (m, 2H), 1.72 (m, 1H).

Sources & evidence

ORD record
ord-72f2f269c35542398f9ad665d5d4f75e
Source dataset
uspto-grants-2010_11
Patent number
US07825256B2

Reaction notes

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