Ammonia → HCID 11640543, compound

HRID 1170496Notes

Reaction equation

C(O[C:4](=[O:32])[CH2:5][N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH2:22][C:23]1[CH:31]=[CH:30][C:26]2[O:27][CH2:28][O:29][C:25]=2[CH:24]=1)[CH3:21])[C:7]1[S:11][N:10]=[C:9]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[N:8]=1)C.[NH3:33]>>[O:27]1[C:26]2[CH:30]=[CH:31][C:23]([CH2:22][N:20]([CH3:21])[CH2:19][CH2:18][CH2:17][N:6]([C:7]3[S:11][N:10]=[C:9]([N:12]4[CH:16]=[CH:15][N:14]=[CH:13]4)[N:8]=3)[CH2:5][C:4]([NH2:33])=[O:32])=[CH:24][C:25]=2[O:29][CH2:28]1

Participants

Reactant 2

HCID 222Ammonia

HCID 11597761HCID 11597761, compound

Product 1

HCID 11640543HCID 11640543, compound

Procedure

2-[[3-(Benzo[1,3]dioxol-5-ylmethyl-methyl-amino)-propyl]-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetamide was prepared following the procedures described in the preparation of Example 56 using [[3-(benzo[1,3]dioxol-5-ylmethyl-methyl-amino)-propyl]-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetic acid ethyl ester and NH3. [M+H]+ 429.87; 1H NMR (400 MHz, d6-DMSO) δ 8.24 (s, 1H), 7.68 (s, 1H), 7.54 (br s, 1H), 7.18 (br s, 1H), 7.06 (s, 1H), 6.86-6.70 (m, 3H), 5.98 (s, 2H), 3.45-3.35 (m, 4H), 3.31 (s, 2H), 2.36 (m, 2H), 2.10 (s, 3H), 1.72 (m, 2H).

Sources & evidence

ORD record: ord-632813fb079a4aebb23a4f93a4466ac5
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07825256B2

Reaction notes

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