1-[2-(1H-Imidazol-1-yl)-4-thiazolyl]ethanone → HCID 11696398, compound

HRID 1170506Notes

Reaction equation

HRID 1170506 reaction equation
[N:1]1([C:6]2[S:7][CH:8]=[C:9]([C:11](=O)[CH3:12])[N:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(OC(=O)[N:20]([CH2:31][CH2:32][NH2:33])[CH2:21][C:22]1[CH:30]=[CH:29][C:25]2[O:26][CH2:27][O:28][C:24]=2[CH:23]=1)(C)(C)C>>[O:26]1[C:25]2[CH:29]=[CH:30][C:22]([CH2:21][NH:20][CH2:31][CH2:32][NH:33][CH:11]([C:9]3[N:10]=[C:6]([N:1]4[CH:5]=[CH:4][N:3]=[CH:2]4)[S:7][CH:8]=3)[CH3:12])=[CH:23][C:24]=2[O:28][CH2:27]1

Participants

3

Reactant 2

HCID 586543761-[2-(1H-Imidazol-1-yl)-4-thiazolyl]ethanoneHCID 68695742HCID 68695742, compound

Product 1

HCID 11696398HCID 11696398, compound

Procedure

N-Benzo[1,3]dioxol-5-ylmethyl-N′-[1-(2-imidazol-1-yl-thiazol-4-yl)-ethyl]-ethane-1,2-diamine was prepared following the procedures described in the preparation of Example 64 using 1-(2-imidazol-1-yl-thiazol-4-yl)-ethanone and (2-amino-ethyl)-benzo[1,3]dioxol-5-ylmethyl-carbamic acid tert-butyl ester. [M+H]+ 372.01; 1H NMR (400 MHz, d6-DMSO) δ 8.38 (s, 1H), 7.82 (d, 1H), 7.31 (s, 1H), 7.18 (d, 1H), 6.92 (d, 1H), 6.84 (d, 1H), 6.77 (dd, 1H), 6.00 (s, 2H), 4.14 (br s, 2H), 3.82 (q, 1H), 3.60 (s, 2H), 3.21 (s, 2H), 2.57 (s, 2H), 1.34 (d, 3H).

Sources & evidence

ORD record
ord-54e4ec7812294522a85e82d76e72f4c6
Source dataset
uspto-grants-2010_11
Patent number
US07825256B2

Reaction notes

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