HCID 17979906, compound → HCID 11611809, compound

HRID 1170518Notes

Reaction equation

HRID 1170518 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH:12]=O)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[N:14]1([C:19]2[N:24]=[C:23]([CH:25]3[CH2:29][CH2:28][CH2:27][N:26]3[CH2:30][CH2:31][NH2:32])[CH:22]=[C:21]([CH3:33])[N:20]=2)[CH:18]=[CH:17][N:16]=[CH:15]1>>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][NH:32][CH2:31][CH2:30][N:26]3[CH2:27][CH2:28][CH2:29][CH:25]3[C:23]3[CH:22]=[C:21]([CH3:33])[N:20]=[C:19]([N:14]4[CH:18]=[CH:17][N:16]=[CH:15]4)[N:24]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 17979906HCID 17979906, compoundHCID 59551924HCID 59551924, compound

Product 1

HCID 11611809HCID 11611809, compound

Procedure

[2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-ethyl]-{2-[2-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-pyrrolidin-1-yl]-ethyl}-amine was prepared following the procedures described in the preparation of Example 127 using (2,3-dihydro-benzo[1,4]dioxin-6-yl)-acetaldehyde and 2-[2-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-pyrrolidin-1-yl]-ethylamine. [M+H]+ 435.54; 1H NMR (400 MHz, CDCl3) δ 8.59 (s, 1H), 7.85 (s, 1H), 7.15 (s, 1H), 7.10 (s, 1H), 6.75 (d, 1H), 6.70-6.60 (m, 2H), 4.18 (s, 4H), 3.54 (t, 1H), 3.15 (m, 1H), 2.94-2.74 (m, 5H), 2.52 (s, 3H), 2.40-2.20 (m, 4H), 1.95-1.66 (m, 4H).

Sources & evidence

ORD record
ord-fad3e993d1ce426aa2829d401283fcdd
Source dataset
uspto-grants-2010_11
Patent number
US07825256B2

Reaction notes

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