Dichloromethane → HCID 58654450, compound

Participants

Reaction Steps

[1-(2-Benzo[1,3]dioxol-5-yl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester (447.1 mg, 1.23 mmol) was dissolved in 1:1 TFA:DCM (6 mL) and stirred at room temperature for 3 hours. After this time, the solvent was removed by vacuum. The crude material was dissolved in DCM (75 mL) and washed with 1M NaOH (aq) (75 mL) to afford the crude product as the freebase. The product was purified by Flash Chromatography (0-10% methanol/DCM gradient) to afford 270.7 mg (83.5%) of the pure product, 2-amino-N-(2-benzo[1,3]dioxol-5-yl-ethyl)-3-methyl-butyramide. [M+H]+ 265.1

Provenance & Evidence