HCID 58654368, compound → HCID 58654395, compound

HRID 1170542Notes

Reaction equation

C(O[C:4](=[O:21])[CH2:5][CH2:6][CH:7]([NH2:20])[C:8]1[CH:13]=[C:12]([CH3:14])[N:11]=[C:10]([N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)[N:9]=1)C.[C:22]([O:26][C:27](=[O:43])[N:28]([CH2:32][C:33]1[CH:42]=[CH:41][C:36]2[O:37][CH2:38][CH2:39][O:40][C:35]=2[CH:34]=1)[CH2:29][CH:30]=O)([CH3:25])([CH3:24])[CH3:23]>>[C:22]([O:26][C:27](=[O:43])[N:28]([CH2:32][C:33]1[CH:42]=[CH:41][C:36]2[O:37][CH2:38][CH2:39][O:40][C:35]=2[CH:34]=1)[CH2:29][CH2:30][N:20]1[C:4](=[O:21])[CH2:5][CH2:6][CH:7]1[C:8]1[CH:13]=[C:12]([CH3:14])[N:11]=[C:10]([N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)[N:9]=1)([CH3:23])([CH3:24])[CH3:25]

Participants

Reactant 2

HCID 58654368HCID 58654368, compound

HCID 86605235HCID 86605235, compound

Product 1

HCID 58654395HCID 58654395, compound

Procedure

(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-{2-[2-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-5-oxo-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester was prepared following the procedures described in the preparation of Example 77c using 4-amino-4-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-butyric acid ethyl ester and (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-(2-oxo-ethyl)-carbamic acid tert-butyl ester.

Workup

customdescribed in the preparation of Example 77c

Sources & evidence

ORD record: ord-03e77f592ca94d6781e1f7bca100a7f7
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07825256B2

Reaction notes

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