HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Chlorophenylacetic acid → 2-[6-Chloro-5-fluoro-2-(methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-cyclohexyl-2-(4-methoxy-phenyl)-acetamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Chlorophenylacetic acid | HCID 15879 | — |
| Edukt | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Edukt | 4-Methoxybenzaldehyde | HCID 31244 | — |
| Edukt | Methoxyphenylacetic acid | HCID 107202 | — |
| Edukt | 2-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide | HCID 67373623 | — |
| Produkt | 2-[6-Chloro-5-fluoro-2-(methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-cyclohexyl-2-(4-methoxy-phenyl)-acetamide | HCID 67373925 | — |
Reaktionsschritte
The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with anisaldehyde ([CAS RN 123-11-5]) and (3-chloro-phenyl)-acetic acid with DL-α-methoxyphenylacetic acid ([CAS RN 7021-09-2]). MS (ISP): 536.3 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07825258B2 |
| Quelldatensatz | uspto-grants-2010_11 |
| ORD ID | ord-e487dabb3f8f4f8bace173827899d43d |
| Quellennotiz | uspto-grants-2010_11 |