3-Chlorobenzaldehyde → 2-[6-Chloro-2-(cyclohexyl-methoxy-methyl)-5-fluoro-benzoimidazol-1-yl]-2-(3-chloro-phenyl)-N-cyclohexyl-acetamide
반응식
[CH2:1]([C:8]1[N:12]([CH:13]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:14]([NH:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[C:11]2[CH:29]=[C:30]([Cl:34])[C:31]([F:33])=[CH:32][C:10]=2[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1([CH:41]=[O:42])CCCCC1.[Cl:43]C1C=C(C=CC=1)C=O.ClC1C=C(CC(O)=O)C=CC=1.C1(C(OC)C(O)=O)CCCCC1>>[Cl:34][C:30]1[C:31]([F:33])=[CH:32][C:10]2[N:9]=[C:8]([CH:1]([CH:2]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)[O:42][CH3:41])[N:12]([CH:13]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:43])[CH:24]=3)[C:14]([NH:16][CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:15])[C:11]=2[CH:29]=1참가 물질
6
반응물 5
생성물 1
실험 절차
The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with 3-chlorobenzaldehyde ([CAS RN 587-04-2]) and (3-chloro-phenyl)-acetic acid with DL-cyclohexyl-methoxy-acetic acid ([CAS RN 15540-18-8]). MS (ISP): 546.3 [M+H]+.
출처 및 근거
- ORD 기록
- ord-f99baf3593cb4b55bccd4ecdcc0445a2
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07825258B2
반응 노트
불러오는 중…