HCID 72479573, compound → HCID 23112893, compound

Participants

Reaction Steps

PtO2 (30 mg) is added to a solution of a E/Z isomers mixture of ethyl (1-(3,4-dichlorophenyl)-1,5,6,7-tetrahydro-4H-indazol-4-ylidene)acetate (1.5 g, 4.27 mmol) in acetic acid (25 mL); the mixture is maintained under stirring under a pressure of 1 H2 atm. A sample is next extracted and a 1H NRM is done. The mixture is then filtered, diluted with AcOEt, and washed with H2O and with a saturated solution of NaHCO3. The solvent is next evaporated at reduced pressure, giving ethyl 2-(1-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetate (1.0 g, 2.83 mmol, purity 66%, oil).

Provenance & Evidence