Phosphorus oxychloride → HCID 86761207, compound

Participants

Reaction Conditions

Reaction Steps

2.65 g (10 mmol) of 2-hydroxy-3-phenylquinoline-4-carboxylic acid (3a) was added into POCl3 (30 mL) and heated at 150° C. for 48 hrs (TLC monitoring). After cooling, the mixture was poured into ice-water (150 mL) to result in precipitation, followed by filtration. The resultant filter cake was poured into 5% NaHCO3(aq) (200 mL) with vigorous stirring for 1 hr, washed with H2O, and dried to give a brown solid, which was recrystallized with EtOH to give the title compound 4a as a red solid (2.31 g, 87% yield).

Provenance & Evidence