Isatin → HCID 178488823, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of isatin (2.21 g, 15 mmol), 3,4-dimethoxyphenylacetic acid (4.91 g, 25 mmol) and sodium acetate (0.3 g) was heated at 200° C. for 3 hrs (TLC monitoring). After cooling, the mixture was added with AcOH (100 mL), and the precipitate was collected, washed with H2O, and dried to give 2-hydroxy-3-[(3,4-dimethoxy)phenyl]quinoline-4-carboxylic acid as a crude intermediate, which was used in the next step without further purification.

Provenance & Evidence