(3-(Benzyloxy)pyridin-2-yl)methanol → 3-(Benzyloxy)pyridine-2-carbaldehyde

HRID 1170911Notes

Reaction equation

HRID 1170911 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([CH2:15][OH:16])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[C:10]([CH:15]=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 13217540(3-(Benzyloxy)pyridin-2-yl)methanol

Product 1

HCID 133745943-(Benzyloxy)pyridine-2-carbaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

(3-(benzyloxy)pyridin-2-yl)methanol (87 g, 400 mmol) was dissolved in anhydrous dioxane (80 mL). Manganese dioxide (351 g) was added and the mixture was heated for 2 hours at 80° C.

Sources & evidence

ORD record
ord-affb1417d5eb4e23978abd14ac0bd9c7
Source dataset
uspto-grants-2010_11
Patent number
US07829572B2

Reaction notes

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