Tetrahydrofuran → HCID 59553878, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-benzyloxy-phenyl)-5-chloro-3-phenethyl-3H-pyrido[4,3-d]pyrimidin-4-one, sodium hydride (60% suspension in mineral oil) (1.5 equiv.), and corresponding alcohol (1.5 equiv.) in THF was heated at 70° C. overnight. The reaction was cooled to RT, solvent removed, water and ethyl acetate were added and phases separated. The aqueous phase was washed with ethyl acetate (2×), organic portions combined, washed with water, brine, dried over anhydrous MgSO4, filtered and concentrated. The residue was purified on preparative TLC plate using 1:1 ethyl acetate:heptane.

Provenance & Evidence