反应详情

温度

90 °C

3-(1-(3,4-difluorophenyl)propan-2-yl)-2-(3-hydroxypyridin-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one (5.90 g, 12.7 mmol) was dissolved in 500 mL of 4-methyl-2-pentanone. To this solution, manganese dioxide was added (16.6 g, 191 mmol) and the mixture was heated to 90° C. for 1 hour. The reaction was cooled, filtered through Celite and washed with CH2CL2. The filtrate was collected and concentrated in vacuo as a yellow solid which was purified by silica gel chromatography to afford the racemic mixture 3-(1-(3,4-difluorophenyl)propan-2-yl)-2-(3-hydroxypyridin-2-yl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one.

1. temperatureThe reaction was cooled
2. filtrationfiltered through Celite
3. washwashed with CH2CL2
4. customThe filtrate was collected
5. concentrationconcentrated in vacuo as a yellow solid which
6. customwas purified by silica gel chromatography